Laboratory of Stem Cell Regeneration and Adaptation

2024

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Yamaoka Y, Chan WI, Seno S, Iwamori K, Fukada SI, Matsuda H.

Quantifying the recovery process of skeletal muscle on hematoxylin and eosin stained images via learning from label proportion

Sci. Rep. 2024 2024 Nov 7;14(1):27044. doi: 10.1038/s41598-024-78433-z..

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Kamizaki K, Katsukawa M, Yamamoto A, Fukada SI, Uezumi A, Endo M, Minami Y

Ror2 signaling regulated by differential Wnt proteins determines pathological fate of muscle mesenchymal progenitors

Cell Death Dis. 2024 Oct 29;15(10):784. doi: 10.1038/s41419-024-07173-9.

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Iwamori K#, Kubota M#, Zhang L#, Kodama K, Kubo A, Kokubo H, Akimoto T, Fukada SI*

Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise

Skeletal Muscle. 2024 Oct 24;14(1):25. doi: 10.1186/s13395-024-00357-z. (# equal contributed)

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Kawata S, Seki S, Nishiura A, Kitaoka Y, Iwamori K, Fukada SI, Kogo M, Tanaka S
Preservation of masseter muscle until the end stage in the SOD1G93A mouse model for ALS.

Sci Rep. 2024, Oct 16;14(1):24279. doi: 10.1038/s41598-024-74669-x.

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Fujii I, Kinoshita R, Akiyama H, Nakamura A, Iwamori K, Fukada SI, Honda H, Shimizu K.
Discovery of fibroblast growth factor 2-derived peptides for enhancing mice skeletal muscle satellite cell proliferation

Biotechnol J.. 2024 Aug;19(8):e2400278. doi: 10.1002/biot.202400278.

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Zhang L#, Saito H#, Higashimoto T, Kaji T, Nakamura A, Iwamori K, Nagano R, Motooka D, Okuzaki D, Uezumi A, Seno S, Fukada SI*

Regulation of muscle hypertrophy through granulin: Relayed communication among mesenchymal progenitors, macrophages, and satellite cells.

Cell Rep. 2024 Apr 3;43(4):114052. doi: 10.1016/j.celrep.2024.114052 (# equal contributed)

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Kang X, Zhao K, Huang Z, Fukada SI*, Gi X*, Miao H*.

Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs

Genes & Diseases in press, Review

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2023

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Veithen M, Huyghe A, Van Den Ackerveken P, Fukada SI, Kokubo H, Breuskin I, Nguyen L, Delacroix L, Malgrange B

Sox9 inhibits cochlear hair cell fate by upregulating Hey1 and HeyL antagonists of Atoh1

Cells. 12(17):2148. 2023

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Kang X, Gao Y, Fukada SI*, Miao H.

FAP senescence: a critical event in muscle regeneration.

Signal Transduct Target Ther. 2023 May 10;8(1):195. doi: 10.1038/s41392-023-01411-w.

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Kubota M, Zhang L, Fukada SI*.

Flow Cytometer Analyses, Isolation, and Staining of Murine Muscle Satellite Cells

Methods Mol Biol 2023;2640:3-11. doi: 10.1007/978-1-0716-3036-5_1.

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Fukada SI*, Uezumi A.

Roles and heterogeneity of mesenchymal progenitors in muscle homeostasis, hypertrophy, and disease.

Stem Cells 2023 Mar 21:sxad023. doi: 10.1093/stmcls/sxad023,  Review

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2022

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Kurosawa T, Ikemoto-Uezumi M, Kaneshige A, Fukada SI, Uezumi A.

Whole-mount immunofluorescence staining of mesenchymal progenitors in murine plantaris muscle

STAR Protocols (Cell Press) 3(3):101593. doi: 10.1016/j.xpro.2022.1015932022, 2022

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Fukada SI*, Higashimoto T, Kaneshige A

Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration

Skeletal Muscle 12(1):17. doi: 10.1186/s13395-022-00300-0., 2022,  Review

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Kaneshige A, Kaji T, Saito H, Higashimoto T, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Uezumi A, and Fukada SI*

Detection of muscle stem cell-derived myonuclei in murine overloaded muscles

STAR Protocols (Cell Press) 11;3(2):101307. doi: 10.1016/j.xpro.2022.101307, 2022

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Sakai H, Sawada Y, Tokunaga N, Tanaka K, Nakagawa S, Sakakibara I, Ono Y, Fukada SI, Ohkawa Y, Kikugawa T, Saika T, Imai Y: 

Uhrf1 governs the proliferation and differentiation of muscle satellite cells.

iScience, 25(3):103928. doi: 10.1016/j.isci.2022.103928, 2022

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Ato S, Fukada SI, Kokubo H, Ogasawara R.

Implication of satellite cell behaviors in capillary growth via VEGF expression-independent mechanism in response to mechanical loading in HeyL-null mice.

Am J Physiol Cell Physiol. doi: 10.1152/ajpcell.00343.2021. 2022

 

Kaneshige A, Kaji T, Zhang L, Saito H, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Tsujikawa K, Seno S, Hori M, Saito Y, Matozaki T, Maehara K, Ohkawa Y, Potente M, Watanabe S, Braun T, Uezumi A*, Fukada SI*

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Cell Stem Cell 29(2):265-280.e6, 2022 

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2021

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Fukada SI*, Ito N

Regulation of muscle hypertrophy: Involvement of the Akt-independent pathway and satellite cells in muscle hypertrophy

Exp Cell Res 2021 Dec 15;409(2):112907.  Review

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Fukada SI*, Nakamura A.

Exercise/Resistance Training and Muscle Stem Cells.

Endocrinol Metab (Seoul) 2021 Aug;36(4):737-744 Review

 

Sakakibara I, Yanagihara Y, Himori K, Yamada T, Sakai H, Sawada Y, Takahashi H, Saeki N, Hirakawa H, Yokoyama A, Fukada SI, Sawasaki T, Imai Y

Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4

iScience  2021 Mar 13;24(4):102303.

 

Zhang L, Kubota M, Nakamura A, Kaji T, Seno S, Uezumi A, Andersen DC, Jensen CH, Fukada SI*

Dlk1 regulates quiescence in calcitonin receptor-mutant muscle stem cells.

Stem Cells 2021 Mar;39(3):306-317.

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Iio H, Kikugawa T, Sawada Y, Sakai H, Yoshida S, Yanagihara Y, Ikedo A, Saeki N, Fukada SI, Saika T, Imai Y.

DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration

​Biochem Biophys Res Commun 2021 Jan 1;534:79-85. doi: 10.1016/j.bbrc.2020.11.116

 

Uezumi A, Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Nakatani M, Hitachi K, Yamaguchi H, Wakatsuki S, Araki T, Morita M, Yamada H, Toyoda M, Kanazawa N, Nakazawa T, Hino J, Fukada SI, Tsuchida K.

Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia

J. Clin. Invest​  2021 Jan 4;131(1):e139617.

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2020

Fukada SI*, Akimoto T, Sotiropoulos A

Role of damage and management in muscle hypertrophy: Different behaviors of muscle

stem cells in regeneration and hypertrophy

BBA-MCR  2020 Sep;1867(9):118742 Review

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Sakai H, Sato T, Kanagawa M, Fukada S, Imai Y

Androgen receptor in satellite cells is not essential for muscle regenerations

Experimental Results 2020 July 29. 1, e21, 1-9. doi:10.1017/exp.2020.14.

 

Yoshimoto Y, Ikemoto-Uezumi M, Hitachi K, Fukada SI, Uezumi A.

Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration.

Frontiers in Cell and Dev. Biol, 2020 Apr 22;8:267. doi: 10.3389/fcell.2020.00267.

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Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr.

Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding..

Cell Metabolism 2020 Feb 4;31(2):301-312

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2019

Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI*

The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.

Cell Rep 2019 Nov 19;29(8):2154-2163

 

Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada SI*

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

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Zhang L, Uezumi A, Kaji T, Tsujikawa K, Andersen DC, Jensen CH, Fukada SI*

Expression and Functional Analyses of Dlk1 in Muscle Stem Cells and Mesenchymal Progenitors during Muscle Regeneration

Int. J. Mol. Sci.  2019, 20. 3269 doi:10.3390/ijms20133269

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Ikemoto-Uezumi M*, Uezumi A, Zhang L, Zhou H, Hashimoto N, Okamura K, Matsui Y, Tsukazaki K, Hosoyama T, Nakatani M, Morita M, Yamada H, Tsuchida K, Fukada S*

Reduced expression of calcitonin receptor is closely associated with age‐related loss of the muscle stem cell pool 2(1)

J. Cachexia Sarcopenia Muscle, Rapid Commun. 2019, 

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Noguchi YT, Nakamura M, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada S*

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites.

Development, 2019, 146(4). pii: dev163618s

 

Tanaka Y, Kita S, Nishizawa H, Fukuda S, Fujishima Y, Obata Y, Nagao H, Masuda S, Nakamura Y, Shimizu Y, Mineo R, Natsukawa T, Funahashi T, Ranscht B, Fukada SI, Maeda N, Shimomura I

Adiponectin promotes muscle regeneration through binding to T-cadherin.

Sci. Rep. 2019, 9(1):16.

 

Shirakura K, Ishiba R, Kashio T, Funatsu R, Tanaka T, Fukada SI, Ishimoto K, Hino N, Kondoh M, Ago Y, Fujio Y, Yano K, Doi T, Aird WC, Okada Y.

The Robo4-TRAF7 complex suppresses endothelial hyperpermeability in inflammation.

J Cell Sci. 2019; 132(1):jcs220228.

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Takemoto Y, Inaba S, Zhang L, Tsujikawa K, Uezumi A, Fukada S*.

Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an anti-oxidative-independent mechanism.  

J. Cell. Physiol. 2019; 234(2):1689-1698

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2018

Inaba S, Hinohara A, Tachibana M, Tsujikawa K, Fukada SI*　

Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential.

PLoS One. 2018,13(10):e0205467.

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Takeshita H, Yamamoto K, Nozato S, Takeda M, Fukada SI, Inagaki T, Tsuchimochi H, Shirai M, Nozato Y, Fujimoto T, Imaizumi Y, Yokoyama S, Nagasawa M, Hamano G, Hongyo K, Kawai T, Hanasaki-Yamamoto H, Takeda S, Takahashi T, Akasaka H, Itoh N, Takami Y, Takeya Y, Sugimoto K, Nakagami H, Rakugi H.

Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.

J Cachexia Sarcopenia Muscle. 2018; 9(5):975-986

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Gordish-Dressman H, Willmann R, Dalle Pazze L, Kreibich A, van Putten M, Heydemann A, Bogdanik L, Lutz C, Davies K, Demonbruen AR, Duan D, Elsey D, Fukada SI, Girgenrath M, Patrick Gonzalez J, Grounds MD, Nichols A, Partridge T, Passini M, Sanarica F, Schnell FJ, Wells DJ, Yokota T, Young CS, Zhong Z, Spurney C, Spencer M, De Luca A, Nagaraju K, Aartsma-Rus A.

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic. 

J Neuromuscul Dis. 2018; 5(4):407-417  Review

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Militello G, Hosen MR, Ponomareva Y, Gellert P, Weirick T, John D, Hindi SM, Mamchaoui K, Mouly V, Döring C, Zhang L, Nakamura M, Kumar A, Fukada SI, Dimmeler S, Uchida S.

A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1

J. Mol. Cell Biol. 2018; 10(2):102-117

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Baghdadi MB, Castel D, Machado L, Fukada SI, Birk DE, Relaix F, Tajbakhsh S, Mourikis P.

Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

Nature. 2018; 557:714-718

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Fukada S*; The roles of muscle stem cells in muscle injury, atrophy, and hypertrophy

J.Biochem, 2018, 5:353-8 Review

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2017

Takemoto Y, Inaba S, Zhang L, Baba K, Hagihara K, Fukada S*.

An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in DBA/2-mdx mice

Clin. Nut. Exp. 2017; 16: 13-23

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Kamizaki K, Doi R, Hayashi M, Saji T, Kanagawa M, Toda T, Fukada SI, Ho HH, Greenberg ME, Endo M, Minami Y. The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.

J. Biol. Chem.2017; 292(38):15939-15951

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Honda M, Hidaka K, Fukada S, Sugawa R, Shirai M, Ikawa M, Morisaki T.

Vestigial-like 2 contributes to normal muscle fiber type distribution in mice.

Sci. Rep. 2017 7(1):7168

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Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H. Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.

Biomed Res. 2017 ;38(3):215-219

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Sakai H#, Fukuda S#, Nakamura M, Uezumi A, NoguchiY, Sato T, Morita M, Yamada H, Tsuchida K, TajbakhshS*, Fukada S*.Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

PLoS One 2017, 12(5):e0177516.

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Miyawaki A, Obana M, Mitsuhara Y, Orimoto A, Nakayasu Y, Yamashita T, Fukada S, Maeda M, NakayamaH, Fujio Y.Adult cardiomyocytes restore intrinsic proliferative capacity through STAT3 in murine myocarditis

Sci. Rep. 2017, 7(1):1407.

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Takeshita H, Yamamoto K, Nozato S, Inagaki T, Tsuchimochi H, Shirai M, Yamamoto R, Imaizumi Y, Hongyo K, Yokoyama S, Takeda M, Oguro R, Takami Y, Itoh N, Takeya Y, Sugimoto K, Fukada S, Rakugi H. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice

Sci. Rep. 2017, 7:42323. 

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2016

Rodrigues M, Echigoya Y, Maruyama R, Lim KR, Fukada S, Yokota T. Impaired regenerative capacity and lower revertant fibre expansion in dystrophin-deficient mdx muscles on DBA/2 background.

Sci. Rep. 2016, 6:3837

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Uezumi A, Nakatani M, Ikemoto-Uezumi M, Yamamoto N, Morita M, Yamaguchi A, Yamada H, Kasai T, Masuda S, Narita A, Miyagoe-Suzuki Y, Takeda S, Fukada S, Nishino I, Tsuchida K Cell surface protein profiling identifies distinctive markers of progenitor cells in human skeletal muscle.

Stem Cell Reports, 2016, 7(2):263-78

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Rodrigues M, Echigoya Y, Fukada S, and Yokota T; Current translational research and murine models for Duchenne muscular dystrophy

Journal of Neuromuscular Disease, 2016 3(1):29-48. Review

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2015

Yamaguchi M#, Watanabe Y#, Ohtani T#, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukada S*, Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.

Cell Rep 2015, 13(2):302-14

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Yamaguchi M#, Murakami S#, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S*. Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.

PLoS One. 2015, 10(9):e0138517. 

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Perini I, Elia I, Lo Nigro A, Ronzoni F, Berardi E, Grosemans H, Fukada S, Sampaolesi M. Myogenic induction of adult and pluripotent stem cells using recombinant proteins.

Biochem Biophys Res Commun, 2015, 464: 755-61

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Ishii K, Suzuki N, Mabichi Y, Ito N, Fukada S, Okano H, Takeda S, Akazawa C: Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation during Muscle Regeneration

Stem Cells, 2015, 33: 3017-27

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Pessina P, Kharras Y, Jardi M, Fukada S, Serrano S, Perdiguero E, Munoz-Canovas P: Fibrogenic cell plasticity blunts tissue regeneration and aggravates muscular dystrophy

Stem Cell Reports ,2015, 4: 1046-60

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Ikemoto-Uezumi M, Uezumi A, Tsuchida K, Fukada S, Yamamoto H, Yamamoto N, Shiomi K, Hashimoto N: Pro-IGF-II ameliorates age-related inefficient regenerative response by orchestrating self-reinforcement mechanism of muscle regeneration

Stem Cells, 2015, 33: 2456-68

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Ogawa R#, Ma Y#, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S*: Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.

Development, 2015, 142: 51-61

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Uezumi A and Fukada S* Toward regenerative medicine for muscular dystrophies-Lessons from regeneration processes- ISBN 978-94-007-5957-2

Translational Research in Muscular Dystrophy, Springer,, 2015 103-22 Review

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2014

Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, Yamaguchi A, Yamada H, Nishino I, Hamada Y, Tsuchida K: Identification and characterization of PDGFRα+ mesenchymal progenitors in human skeletal muscle

Cell Death & Disease, 2014, 5:e1186.

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Doi R, Endo M, Yamakoshi K, Yamanashi Y, Nishita M, Fukada S, Minami Y: Critical role of Frizzled1 in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation

Genes to Cells, 2014, 19(4): 287-96

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Mikami N, Sueda K, Ogitani Y, Otani I, Takatsuji M, Wada Y, Watanabe K, Yoshikawa R, Nishioka S, Hashimoto N, Miyagi Y, Fukada S*, Yamamoto H, Tsujikawa K: Calcitonin Gene-Related Peptide Regulates Type IV Hypersensitivity through Dendritic Cell Function

PLoS One. 2014, 9(1):e86367

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Fukada S*, Ma Y., and Uezumi A; Adult stem cell or mesenchymal progenitors theories for aging.

Frontiers in Cell and Dev. Biol., 10.3389/fcell.2014.00010, 2014 Review

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