Laboratory of Stem Cell Regeneration and Adaptation

 Alumni 

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金重　紀洋（在籍2018-21年度）

【博士論文】

間葉系前駆細胞を介した骨格筋の過負荷応答

【原著論文】

◯Kaneshige A, Kaji T, Zhang L, Saito H, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Tsujikawa K, Seno S, Hori M, Saito Y, Matozaki T, Maehara K, Ohkawa Y, Potente M, Watanabe S, Braun T, Uezumi A*, Fukada SI

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Cell Stem Cell 29(2):265-280.e6, 2022 

◯Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada S

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

【総説・解説】

◯Kaneshige A, Kaji T, Saito H, Higashimoto T, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Uezumi A, and Fukada SI*Detection of muscle stem cell-derived myonuclei in murine overloaded muscles

STAR Protocols (Cell Press) in press

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梶　貴志（在籍2017-20年度）

【修士論文】

筋肥大における筋線維核増加機構

【原著論文】

◯Kaneshige A, Kaji T, Zhang L, Saito H, Nakamura A, Kurosawa T, Ikemoto-Uezumi M, Tsujikawa K, Seno S, Hori M, Saito Y, Matozaki T, Maehara K, Ohkawa Y, Potente M, Watanabe S, Braun T, Uezumi A*, Fukada SI

Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

Cell Stem Cell 29(2):265-280.e6, 2022 

◯Zhang L, Kubota M, Nakamura A, Kaji T, Seno S, Uezumi A, Andersen DC, Jensen CH, Fukada SI

Dlk1 regulates quiescence in calcitonin receptor-mutant muscle stem cells

Stem Cells, 2021 Mar;39(3):306-317.

◯Zhang L,Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI

The CalcR-PKA-Yap1 axis is critical for maintaining 1 quiescence in muscle stem cells. 

Cell Rep. 2019 Nov 19;29(8):2154-2163

◯Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada S

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

◯Zhang L, Uezumi A, Kaji T, Tsujikawa K, Andersen DC, Jensen CH, Fukada SI.

Expression and Functional Analyses of Dlk1 in Muscle Stem Cells and Mesenchymal Progenitors during Muscle Regeneration

Int J Mol Sci. 2019 Jul 3;20(13):3269

【総説】

梶　貴志，深田宗一朗：「筋肥大時の筋サテライト細胞の動態・分化様式―多核細胞である筋線維がさらに核を増やす意義・機構」

実験医学, 10月号，p2681-2685, 2020

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張　礫丹（在籍2014-20年度）

【博士論文】

カルシトニン受容体を介した筋幹細胞の静止期維持メカニズムの解明

【原著論文】

 ◯Zhang L, Kubota M, Nakamura A, Kaji T, Seno S, Uezumi A, Andersen DC, Jensen CH, Fukada SI

Dlk1 regulates quiescence in calcitonin receptor-mutant muscle stem cells

Stem Cells, 2021 Mar;39(3):306-317.

◯Zhang L,Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI

The CalcR-PKA-Yap1 axis is critical for maintaining 1 quiescence in muscle stem cells. 

Cell Rep. 2019 Nov 19;29(8):2154-2163 

◯Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada S

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

◯Zhang L, Uezumi A, Kaji T, Tsujikawa K, Andersen DC, Jensen CH, Fukada SI.

Expression and Functional Analyses of Dlk1 in Muscle Stem Cells and Mesenchymal Progenitors during Muscle Regeneration

Int J Mol Sci. 2019 Jul 3;20(13):3269

◯Noguchi YT#, Nakamura M,#, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada S (# equal first)

Development,  2019 Feb 20;146(4).

◯Takemoto Y, Inaba S, Zhang L, Tsujikawa K, Uezumi A, Fukada S.

Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an anti-oxidative-independent mechanism.

J. Cell. Physiol. 2019; 234(2):1689-1698

◯Takemoto Y, Inaba S, Zhang L, Baba K, Hagihara K, Fukada S.

An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in DBA/2-mdx mice

Clin. Nut. Exp. 2017; 16: 13-23

◯Militello G, Hosen MR, Ponomareva Y, Gellert P, Weirick T, John D, Hindi SM, Mamchaoui K, Mouly V, Döring C, Zhang L, Nakamura M,  Kumar A, Fukada SI, Dimmeler S, Uchida S. A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1

J. Mol. Cell Biol. 2018; 10(2):102-117

◯Takei D, Nishi M, Fukada S, Doi M, Okamura H, Uezumi A, Zhang L, Yoshida M, Miyazato M, Ichimura A, Takeshima H.

Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.

Biomed Res. 2017;38(3):215-219.

◯Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S.

Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.

PLoS One. 2015, 10(9):e0138517

【総説】

張礫丹，深田宗一朗: 「組織幹細胞からみた筋と骨の加齢変化」　

The Bone 2015, 29 (3): 27-31

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福田純明（在籍2017-19年度）

【博士論文】過負荷筋における骨格筋幹細胞の活性化・増殖メカニズム解明

【原著論文】

◯Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada S*

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

◯Sakai H#, Fukuda S#, Nakamura M, Uezumi A, NoguchiY, Sato T, Morita M, Yamada H, Tsuchida K, TajbakhshS*, Fukada S*.

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

PLoS One  2017, 12(5):e0177516.

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野口祐太郎（在籍2015-18年度）

【修士論文】Hey-Hes1 ヘテロダイマーによる筋幹細胞の未分化維持

【原著論文】

◯Zhang L, Noguchi YT, Nakayama H, Kaji T, Tsujikawa K, Ikemoto-Uezumi M, Uezumi A, Okada Y, Doi T, Watanabe S, Braun T, Fujio Y, Fukada SI

The CalcR-PKA-Yap1 Axis Is Critical for Maintaining Quiescence in Muscle Stem Cells.

Cell Reports 2019 Nov 19;29(8):2154-2163

◯Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada S

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

◯Noguchi YT#, Nakamura M,#, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada S (# equal first)

Development,  2019 Feb 20;146(4). 

◯Sakai H#, Fukuda S#, Nakamura M, Uezumi A, Noguchi YT, Sato T, Morita M, Yamada H, Tsuchida K, TajbakhshS*, Fukada S*.

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

PLoS One  2017, 12(5):e0177516.

【総説】

◯野口祐太郎, 深田宗一朗:「筋の発生と再生メカニズムの解明」　

Clinical Calcium  2018;28(3):329-333

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稲葉翔也（在籍2015-18年度）

【長期課題論文】In vivo薬物評価系としての、重篤な筋ジストロフィーマウスの有用性

【原著論文】

◯Inaba S, Hinohara A, Tachibana M, Tsujikawa K, Fukada S

Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential.

PLoS One  2018; 13(10):e0205467

◯Takemoto Y, Inaba S, Zhang L, Tsujikawa K, Uezumi A, Fukada S*.

Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an anti-oxidative-independent mechanism.

J. Cell. Physiol. 2019; 234(2):1689-1698

◯Takemoto Y, Inaba S, Zhang L, Baba K, Hagihara K, Fukada S*.

An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in DBA/2-mdx mice

Clin. Nut. Exp. 2017; 16: 13-23

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竹本裕政（在籍2016-17年度）

【修士論文】筋衛星細胞におけるNrf2の役割の解明

【原著論文】

◯Fukuda S, Kaneshige A, Kaji T, Noguchi YT, Takemoto Y, Zhang L, Tsujikawa K, Kokubo H, Uezumi A, Maehara K, Harada A, Ohkawa Y, Fukada S*

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle.

eLife  2019 Sep 23;8. pii: e48284.

◯Takemoto Y, Inaba S, Zhang L, Tsujikawa K, Uezumi A, Fukada S*.

Implication of basal lamina dependency in survival of Nrf2-null muscle stem cells via an anti-oxidative-independent mechanism.

J. Cell. Physiol. 2019; 234(2):1689-1698

◯Takemoto Y, Inaba S, Zhang L, Baba K, Hagihara K, Fukada S*.

An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in DBA/2-mdx mice

Clin. Nut. Exp. 2017; 16: 13-23

【総説】

◯竹本裕政, 深田宗一朗:「筋幹細胞の維持機構解明から制御へ」

実験医学、増刊号、2018;36(7):96-101

◯竹本裕政, 深田宗一朗:「筋衛星細胞の維持機構及び加齢性筋萎縮への関与」　

Clinical Calcium  2017;27(3):339-344

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中村美紀（在籍2014-15年度）

【修士論文】Hey1, HeyLを介した骨格筋幹細胞維持メカニズムに関する検討

【原著論文】

◯Noguchi YT#, Nakamura M#, Hino N, Nogami J, Tsuji S, Sato T, Zhang L, Tsujikawa K, Tanaka T, Izawa K, Okada Y, Doi T, Kokubo H, Harada A, Uezumi A, Gessler M, Ohkawa Y, Fukada S* (# equal first)

Development, 2019, Feb 20;146(4). 

◯Militello G, Hosen MR, Ponomareva Y, Gellert P, Weirick T, John D, Hindi SM, Mamchaoui K, Mouly V, Döring C, Zhang L, Nakamura M,

Kumar A, Fukada SI, Dimmeler S, Uchida S. A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1

J. Mol. Cell Biol. 2018; 10(2):102-117

◯Sakai H#, Fukuda S#, Nakamura M, Uezumi A, NoguchiY, Sato T, Morita M, Yamada H, Tsuchida K, TajbakhshS*, Fukada S*.

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

PLoS One  2017, 12(5):e0177516.

◯Yamaguchi M#, Watanabe Y#, Ohtani T#, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukada S*

Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche.

Cell Reports 2015, 13(2):302-14

◯Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S*.

Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated State.

PLoS One. 2015, 10(9):e0138517

◯Ogawa R#, Ma Y#, Yamaguchi M, Ito T, Watanabe Y, Ohtani T, Murakami S, Uchida S, De Gaspari P, Uezumi A, Nakamura M, Miyagoe-Suzuki Y, Tsujikawa K, Hashimoto N, Braun T, Tanaka T, Takeda S, Yamamoto H, Fukada S*: Doublecortin marks a new population of transiently amplifying muscle progenitor cells and is required for myofiber maturation during skeletal muscle regeneration.

Development, 2015, 142: 51-61